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Peer-Reviewed Publications

  • N Brookhouser*, T Nguyen*, SJ Tekel*, K Standage-Beier*, X Wang, DA Brafman (2020). CasMAS (XMAS)-TREE: A Cas9-Mediated Adenosine Transient Reporter for Editing Enrichment (CasMAsTREE). (In review). *co-first author

  • N Brookhouser*, SJ Tekel*, K Standage-Beier*, T Nguyen, G Schwarz, X Wang, DA Brafman. (2020). BIG-TREE: Base-edited isogenic hiPSC line generation using a transient reporter for editing enrichment. Stem Cell Reports, Volume 14, 11 February 2020, pg 184-191.  *co-first author

  • K Standage-Beier*, SJ Tekel*, N Brookhouser*, G Schwarz, T Nguyen, X Wang, DA Brafman. (2019). A Transient Reporter for Editing Enrichment (TREE) in Human Cells. Nucleic Acids Research. doi: 10.1093/nar/gkz713. *co-first author

  • SJ Tekel, CL Smith, B Lopez, A Mani, C Connot, X Livingstone, KA Haynes (2019). Engineered orthogonal Quorum Sensing Systems for Synthetic Gene Regulation in Escherichia coli. Frontiers of Bioengineering and Biotechnology. 7:80.

  • R Daer, CM Barrett, EL Melendez, J Wu, SJ Tekel, J Xu, B Dennison, R Muller, KA Haynes (2018). Characterization of Diverse Homoserine Lactone Synthases in Escherichia coli. PloS One. 13(8): e0202294.

  • SJ Tekel, CM Barrett, DA Vargas, KA Haynes (2018). Design, construction, and validation of histone-binding effectors in vitro and in cells. ACS Biochemistry, Volume 57, Issue 31, 4707-4716.

  • SJ Tekel, DA Vargas, L Song, J LaBaer, MR Caplan, KA Haynes (2018). Tandem Histone-Binding Domains Enhance the Activity of a Synthetic Chromatin Effector. ACS Synthetic Biology, Volume 7, Issue 3, 12 February 2018, pg 842-852

  • SJ Tekel, KA Haynes (2017) Molecular Structures Guide the Engineering of Chromatin. Nucleic Acids Research, Volume 45, Issue 13, 27 July 2017, pg 7555-7570


Synthetic Transcriptional Regulator Compositions and Methods - Filed February 13, 2019. Application number: 16/274,770.

Transient Reporters and Methods for Base Editing Enrichment - Filed June 12, 2020. Application number: 63/038,220

Recent Conference Events

(2019) A Transient Reporter for Editing Enrichment (TREE) enables detection and isolation of single base edited cell lines-Engineering Biology Research Consortium (EBRC), Boston, MA


(2018) A Versatile Phenotypic Reporter for Cas9 Base Editing of Disease Relevant SNPs- Engineering Biology Research Consortium (EBRC), Fort Collins, CO


(2018) Generation of Disease Relevant Isogenic Stem Cell Lines Using Cas9 Base Editors – Synthetic Biology: Engineering, Evolution & Design (SEED), Scottsdale, AZ

(2018) Delivery of functional epigenetic regulators- Engineering Biology Research Consortium (EBRC), Seattle, WA

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